Andrew J. Sharp, PhD

Senior Faculty Member and Associate Professor, Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York.

Dr. Sharp is a recognized global authority on structural genome variation and its role in human disease. He has published more than 40 peer-reviewed research and review articles in top medical journals including Nature Genetics and The New England Journal of Medicine, delivered dozens of invited lectures at academic centers and conferences worldwide, and presented numerous scientific abstracts on the subject.

Since joining Mount Sinai in March 2010, Dr. Sharp has been building on more than a decade of applying a reverse genetics approach to his research, where he has made important breakthroughs by analyzing elements of the human genome and linking new observations to a variety of different diseases. His lab is utilizing new and novel technologies to study epigenetic modifications, DNA methylation and gene expression to uncover patterns associated with disease.

Previously, Dr. Sharp spent two and a half years as a Marie Curie Fellow in the Department of Genetic Medicine at University of Geneva, Switzerland, where he was able to identify for the first time specific DNA elements that control gene expression in Prader-Willi and Angelman syndromes.

From May 2004 – September 2007, Dr. Sharp served as a Senior Fellow in the Department of Genome Sciences at University of Washington in Seattle, where he produced some of the seminal research in structural variation, identifying several unstable regions of the human genome that represent syndromes linked to mental retardation, autism, schizophrenia, diabetes and epilepsy.

Dr. Sharp received his PhD at University of Southampton, England in 2003 under the mentorship of Dr. Patricia Jacobs, one of the founding investigators of modern human genetics, where he gained international recognition for his work on X chromosome inactivation. From 1997 – 2003, Dr. Sharp served as a research assistant at the Wessex Regional Genetics Laboratory in Salisbury, England. He earned a B.S. in Biological Sciences at University of Exeter, England in 1995.

Dr. Sharp is a member of the European Society for Human Genetics and American Society for Human Genetics and serves as a frequent reviewer for leading journals such as Nature Genetics and PLoS Genetics.

The recipient of numerous awards dating back to his pre-doctoral research, Dr. Sharp has the unique achievement of having received both the Young Investigator Award for Outstanding Science from the European Society of Human Genetics (2009) and the Trainee Award from the American Society of Human Genetics on two separate occasions (2002 and 2006).

More about Dr. Sharp on the Mount Sinai Medical Center website.