Arthrogryposis Multiplex Congenita (AMC)

Arthrogryposis Multiplex Congenita (AMC) refers to a group of conditions that cause stiff joints and limited joint movement, according to the National Institutes of Health (NIH) Office of Rare Diseases Research. The condition is present at birth, but it is non-progressive. The signs and symptoms of AMC can vary greatly in severity. Physical therapy and sometimes surgery have proven beneficial. While improvements can be made, most patients will have persistent muscular and/or joint limitations due to the underlying condition.

The exact cause of AMC is not fully understood, but it is believed that about 30% of cases are genetic. The carrier frequency in the Ashkenazi Jewish population is 1 in 373.

More information and resources are available at the following websites:

National Organization for Rare Disorder

Arthroryposis Multiplex Congenital Support Inc.

National Center for Advancing Translational Sciences Office of Rare Diseases Research