Dr. Eric Schadt, PhD

Chairman, Department of Genetics and Genomic Sciences; Director, Institute of Genomics and Multiscale Biology; Jean C. and James W. Crystal Professor of Genomics, Mount Sinai School of Medicine, New York City.

Dr. Eric Schadt, a visionary in the use of computational biology in genomics, joined the Mount Sinai School of Medicine in August 2011. His focus is on generating and integrating large-scale, high-dimension molecular, cellular, and clinical data to build more predictive disease models that will improve the ability to diagnosis and treat diseases.

His efforts are motivated by the genomics and systems biology research he led as Executive Scientific Director of Genetics at Rosetta Inpharmatics, a subsidiary of Merck & Co., to elucidate common human diseases and drug response using novel computational approaches applied to genetic and molecular profiling data. His research helped revolutionize a field in statistical genetics (the genetics of gene expression), has energized the systems biology field, and has led to a number of discoveries relating to the causes of common human diseases. When Dr. Schadt left Merck in 2009, more than 50% of all the company’s new drug discovery programs in the metabolic space were derived from his work.

Since June 2009, Dr. Schadt has served as Chief Scientific Officer (CSO) of Pacific Biosciences, overseeing the firm’s scientific strategy including creating the vision for next-generation sequencing applications of the company’s technology. He currently retains that position, and Mount Sinai will use technology platforms from Pacific Biosciences to query biological data.

Dr. Schadt is a founding member of Sage Bionetworks, an open access genomics initiative designed to build and support databases and an accessible platform for creating innovative, dynamic disease models.

Dr. Schadt has co-authored numerous studies on gene expression and analysis published in peer-reviewed medical journals including Nature, Nature Genetics and The New England Journal of Medicine (NEJM).

Recently appointed Fellow to the Institute of Systems and Synthetic Biology, Imperial College London, Dr. Schadt received a Ph.D. in bio-mathematics from the University of California, Los Angeles (UCLA) (requiring Ph.D. candidacy in molecular biology and mathematics); an M.A. in pure mathematics from the University of California, Davis (UCD); and a B.S. in applied mathematics/computer science from California Polytechnic State University.

More information about Dr. Schadt on the Mount Sinai School of Medicine website.